TPDB

TPDB ID TPDB93338

Peptide_Name

Cyclo (His-Pro)

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 5-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

Modified, details unspecified

Sequence

c(HP)

FASTA

>TPDB93338|Blood-Brain Barrier|length=5
c(HP)

Formula C14H21N5O4S1

Absent Amino Acids ARNDEQGILKMFSTWYV

Common Amino Acids CHP

Mass 355.41

PI 7.15

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +0

Boman Index 1.17

Hydrophobicity -0.460

Aliphatic Index 0.00

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

1

C

0

E

0

Q

0

G

1

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C14H21N5O4S1

Mass

355.41

PI

7.15

Net Charge

+0

Boman Index

1.17

Hydrophobicity

-0.460

Conformation

Linear Cyclic

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Cyclo (His-Pro)

SMILES

O=C1N3[C@@H](C(=O)N[C@@H]1Cc2ncnc2)CCC3

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.09

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log P

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.000179 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0239 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 25.6 min

Assay & Model

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0118 min-1

Assay & Model

Animal Model Origin/Source

Response Brain elimination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous