TPDB

TPDB ID TPDB93335

Peptide_Name

LSZ 1025 SAM 1025

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 21-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation Chemical: (D)Cys2-(D)Cys5

Sequence

YcGFc-(β-D-Glc)sG-NH2

FASTA

>TPDB93335|Blood-Brain Barrier|length=21
YcGFc-(β-D-Glc)sG-NH2

Formula C56H78N16O19S3

Absent Amino Acids AREQIKMPTWV

Common Amino Acids CG

Mass 1375.51

PI 4.93

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index -0.58

Hydrophobicity 0.029

Aliphatic Index 18.57

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1615

Absorbance 280nm 117.41

Polar Residues 6

number

0

A

0

R

1

N

1

D

3

C

0

E

0

Q

3

G

1

H

0

I

1

L

0

K

0

M

1

F

0

P

1

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 1 C: 3 E: 0 Q: 0 G: 3 H: 1 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0

Length

21

Formula

C56H78N16O19S3

Mass

1375.51

PI

4.93

Net Charge

-1

Boman Index

-0.58

Hydrophobicity

0.029

Chemical_Modification

(D)Cys2-(D)Cys5

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-(D)Cys-Gly-Phe-(D)Cys-(Î²-D-Glucose)Ser-Gly-NH2 Tyr-(D)Cys-Gly-Phe-(D)Cys-(Î²-D-Glucose) (D)Ser-Gly-NH2

SMILES

O=C(N)CNC(=O)[C@@H](NC(=O)[C@H]2NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)CSSC2)Cc3ccccc3)CO[C@@H]4OC(CO)[C@H](O)C(O)[C@H]4O O=C(N)CNC(=O)[C@@H](NC(=O)[C@@H]2NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)CSSC2)Cc3ccccc3)CO[C@@H]4OC(CO)[C@@H](O)C(O)[C@H]4O

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -1.31

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log D

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -1.252

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log D

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -1.31

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log D

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -1.252

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log D

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination