TPDB

TPDB ID TPDB93330

Peptide_Name

mouse Ghrelin

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 38-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

Modified, details unspecified

Sequence

GSS(octanoyl)FLSPEHQKAQQRKESKKPPAKLQPR

FASTA

>TPDB93330|Blood-Brain Barrier|length=38
GSS(octanoyl)FLSPEHQKAQQRKESKKPPAKLQPR

Formula C168H274N52O50S1

Absent Amino Acids DIMWV

Common Amino Acids K

Mass 3854.40

PI 10.47

Basic Residues 8

Acidic Residues 2

Hydrophobic Residues 8

Net Charge +5

Boman Index 12.28

Hydrophobicity -1.213

Aliphatic Index 38.68

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 38.66

Polar Residues 12

number

3

A

2

R

1

N

0

D

1

C

2

E

4

Q

1

G

1

H

0

I

3

L

5

K

0

M

1

F

4

P

4

S

1

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 3 R: 2 N: 1 D: 0 C: 1 E: 2 Q: 4 G: 1 H: 1 I: 0 L: 3 K: 5 M: 0 F: 1 P: 4 S: 4 T: 1 W: 0 Y: 1 V: 0

Length

38

Formula

C168H274N52O50S1

Mass

3854.40

PI

10.47

Net Charge

+5

Boman Index

12.28

Hydrophobicity

-1.213

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Gly-Ser-Ser(Octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 16.4 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Saturable

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.042 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Saturable

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01 %/g

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.005 %/g

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -1.24

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log P

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination