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Peptide record

TPDB93328

Doxorubicin-(D)-Pene Blood-Brain Barrier modified_plain modified
35 amino acids
Basic Information
TPDB93328
Doxorubicin-(D)-Pene
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 35-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Modified, details unspecified
Sequence
Doxorubicin-linker-rqikiwfqnrrmkwkk
Physicochemical Analysis
C166H277N55O38S2
AGHPSTYV
RIK
3715.49
11.90
10
2
10
+8
7.26
-0.994
66.86
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
11000
296.06
6
Residue Composition
number
0
A
5
R
3
N
1
D
1
C
1
E
2
Q
0
G
0
H
5
I
1
L
5
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 3 D: 1 C: 1 E: 1 Q: 2 G: 0 H: 0 I: 5 L: 1 K: 5 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
35
C166H277N55O38S2
3715.49
11.90
+8
7.26
-0.994
Linear
Similarity
Doxorubicin-linker-(D)Arg-(D)Gln-(D)Ile-(D)Lys-(D)Ile-(D)Trp-(D)Phe-(D)Gln-(D)Asn-(D)Arg-(D)Arg-(D)Met-(D)Lys-(D)Trp-(D)Lys-(D)Lys
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.072 mL/(g x min)

Assay & Model

Origin/Source
Unidirectonal influx rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
In situ perfusion (single time)
Permeability
H3/C14
Additional Detail Fields 1 fields
In situ perfusion (single time)