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Peptide record

TPDB93326

Urocortin-I Blood-Brain Barrier modified_plain modified
44 amino acids
Basic Information
TPDB93326
Urocortin-I
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 44-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Amidation C-terminal: Chemical modification N-terminal: C-terminal modification
Sequence
DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2
Physicochemical Analysis
C216H350N66O68
CGKMWY
L
4959.56
5.34
7
7
15
-2
13.86
-0.570
99.77
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
11
Residue Composition
number
2
A
5
R
2
N
4
D
0
C
3
E
3
Q
0
G
2
H
3
I
7
L
0
K
0
M
2
F
2
P
3
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 5 N: 2 D: 4 C: 0 E: 3 Q: 3 G: 0 H: 2 I: 3 L: 7 K: 0 M: 0 F: 2 P: 2 S: 3 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
44
C216H350N66O68
4959.56
5.34
-2
13.86
-0.570
Chemical modification
Linear
C-terminal modification
Similarity
Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
Evidence Records 7 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.000583 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

frog
Intravenous
Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
13.8 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

frog
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.05 min-1

Assay & Model

Efflux study ICU
Origin/Source
Brain elemination rate constant

Source & Reference

NA
B3Pdb

Other

frog
Permeability
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.000676 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

frog
in situ brain perfusion
Permeability
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
50%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

frog
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
50%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

frog
Direct iodination
Evidence 7 Activity

Activity

Blood-Brain Barrier
91.4 %/g

Assay & Model

HPLC
Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

frog
Direct iodination
Additional Detail Fields 1 fields
Intravenous in situ brain perfusion