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Peptide record

TPDB93321

Tumor-homing Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB93321
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 4-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Conjugation Human heavy-chain ferritin (HFn)
Sequence
RGDK
Physicochemical Analysis
C18H34N8O7
ANCEQHILMFPSTWYV
RDGK
474.52
10.09
2
1
0
+1
3.04
-3.075
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C18H34N8O7
474.52
10.09
+1
3.04
-3.075
Conjugation Human heavy-chain ferritin (HFn)
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Ovarian cancer, Colorectal cancer and Stomach cancer
Alpha-5 beta -3, 5 integrins, Neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Engineered Human Heavy-Chain Ferritin with Half-Life Extension and Tumor Targeting by PAS and RGDK Peptide Functionalization
2021
Yin S et al. Pharmaceutics. 2021 Apr 9 13(4):521.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
4T1 cell line
8 weeks old female BALB/c mice injected with Breast cancer cell line 4T1
Synthetic
Doxorubicin (DOX), Human heavy-chain ferritin (HFn)
Additional Detail Fields 3 fields
Doxorubicin (DOX), Human heavy-chain ferritin (HFn)
4T1 cell line
8 weeks old female BALB/c mice injected with Breast cancer cell line 4T1