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Peptide record

TPDB93309

tLyp1 Tumor-homing Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB93309
tLyp1
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 15-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: NH2-rich linker (GGGGKKKK)
Sequence
AREYGTRFSLIGGYR
Physicochemical Analysis
C78H120N24O22
NDCQHKMPWV
RG
1745.96
10.24
3
1
6
+2
0.70
-0.627
58.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
2980
170.68
4
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
1
E
0
Q
3
G
0
H
1
I
1
L
0
K
0
M
1
F
0
P
1
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
15
C78H120N24O22
1745.96
10.24
+2
0.70
-0.627
NH2-rich linker (GGGGKKKK)
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Ultralong tumor retention of theranostic nanoparticles with short peptide-enabled active tumor homing
2019
Li L et al. Mater Horiz. 2019 6(9):1845-1853.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MCF-7, MCF-10A, SKBR-3, MDA-231
MCF-7 tumor-bearing nude mice
Phage Display Library
Doxorubicin, Gadolinium and diethylenetriamine pentaacetic complex acid (Gd-DTPA), FITC, 3-aminopropyltriethoxysilane (APTES), Succinic anhydride (SA)
Additional Detail Fields 3 fields
Doxorubicin, Gadolinium and diethylenetriamine pentaacetic complex acid (Gd-DTPA), FITC, 3-aminopropyltriethoxysilane (APTES), Succinic anhydride (SA)
MCF-7, MCF-10A, SKBR-3, MDA-231
MCF-7 tumor-bearing nude mice