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Peptide record

TPDB93308

PL3 Tumor-homing Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB93308
PL3
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 8-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
N-terminal: Iron oxide nanoworms (NWs)
Sequence
AGRGRLVR
Physicochemical Analysis
C36H69N17O9
NDCEQHIKMFPSTWY
R
884.05
12.70
3
0
3
+3
1.79
-0.562
97.50
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
8
C36H69N17O9
884.05
12.70
+3
1.79
-0.562
C-end Rule(CendR)
Iron oxide nanoworms (NWs)
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
C-isoform of Tenascin-C (TNC-C), Neuropilin-1(NRP-1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-penetrating peptide for systemic targeting of Tenascin-C
2020
Lingasamy P et al. Sci Rep.2020 Apr 2 10(1):5809.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
U87-MG (human glioblastoma, HTB-14) cells, PC3 (prostate carcinoma, CRL1435) cells, PPC1 (primary prostate carcinoma-1) cells were purchased from ATCC. Murine WT-GBM glioblastoma cells, P3, P8, P13 stem cell-like, P22, NCH421K cells
Athymic nude mice (Hsd/Athymic Fox1 nu Harlan)
Phage display library
T7 phage / CX7C peptide library
Iron oxide nanoworms (NWs)
Additional Detail Fields 4 fields
Iron oxide nanoworms (NWs)
U87-MG (human glioblastoma, HTB-14) cells, PC3 (prostate carcinoma, CRL1435) cells, PPC1 (primary prostate carcinoma-1) cells were purchased from ATCC. Murine WT-GBM glioblastoma cells, P3, P8, P13 stem cell-like, P22, NCH421K cells
Athymic nude mice (Hsd/Athymic Fox1 nu Harlan)
T7 phage / CX7C peptide library