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Peptide record

TPDB93306

Tyr-Melanocyte-stimu Blood-Brain Barrier standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB93306
Tyr-Melanocyte-stimu
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
standard
No
A 4-aa standard natural blood-brain barrier peptide sequence curated from Peptipedia, with an available 3D structural model.
C-terminal: Chemical modification N-terminal: C-terminal modification
Sequence
YPLG
Physicochemical Analysis
C22H32N4O6
ARNDCEQHIKMFSTWV
GLPY
448.52
5.94
0
0
2
-0
-1.04
0.125
97.50
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
332.20
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
4
C22H32N4O6
448.52
5.94
-0
-1.04
0.125
Chemical modification
Linear
C-terminal modification
Similarity
Tyr-Pro-Leu-Gly
O=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2
Evidence Records 3 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
3.54%

Assay & Model

Origin/Source
in vitro influx rate

Source & Reference

NA
B3Pdb

Other

bovine
In situ perfusion (single time)
Saturable
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
1.35%

Assay & Model

Capillary deplition in situ b p
Origin/Source
Gas constant pellet

Source & Reference

NA
B3Pdb

Other

bovine
Saturable
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
3.12%

Assay & Model

Capillary deplition in situ b p
Origin/Source
Gas constant supernatant

Source & Reference

NA
B3Pdb

Other

bovine
Saturable
Direct iodination
Additional Detail Fields 1 fields
In situ perfusion (single time)