TPDB

3D PDB MODEL

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TPDB ID TPDB93305

Peptide_Name

Mahogany (1377-1428)

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 52-aa standard natural blood-brain barrier peptide sequence curated from Peptipedia, with an available 3D structural model.

Modification

C-terminal: Chemical modification N-terminal: C-terminal modification

Sequence

GLGGIPPPGQSGLAVASALVDISQQMPIVYKEKSGAVRNRKQQPPAQPGTCI

FASTA

>TPDB93305|Blood-Brain Barrier|length=52
GLGGIPPPGQSGLAVASALVDISQQMPIVYKEKSGAVRNRKQQPPAQPGTCI

Formula C232H386N68O70S2

Absent Amino Acids HFW

Common Amino Acids GP

Mass 5312.15

PI 10.07

Basic Residues 5

Acidic Residues 2

Hydrophobic Residues 18

Net Charge +3

Boman Index 10.72

Hydrophobicity -0.227

Aliphatic Index 84.42

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 28.05

Polar Residues 14

number

5

A

2

R

1

N

1

D

1

C

1

E

6

Q

7

G

0

H

4

I

3

L

3

K

1

M

0

F

7

P

4

S

1

T

0

W

1

Y

4

V

Amino Acid Distribution

A: 5 R: 2 N: 1 D: 1 C: 1 E: 1 Q: 6 G: 7 H: 0 I: 4 L: 3 K: 3 M: 1 F: 0 P: 7 S: 4 T: 1 W: 0 Y: 1 V: 4

Length

52

Formula

C232H386N68O70S2

Mass

5312.15

PI

10.07

Net Charge

+3

Boman Index

10.72

Hydrophobicity

-0.227

C_terminal_Modification

Chemical modification

Conformation

Linear

N_terminal_Modification

C-terminal modification

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Gly-Leu-Gly-Gly-Ile-Pro-Pro-Pro-Gly-Gln-Ser-Gly-Leu-Ala-Val-Ala-Ser-Ala-Leu-Val-Asp-Ile-Ser-Gln-Gln-Met-Pro-Ile-Val-Tyr-Lys-Glu-Lys-Ser-Gly-Ala-Val-Arg-Asn-Arg-Lys-Gln-Gln-Pro-Pro-Ala-Gln-Pro-Gly-Thr-Cys-Ile

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 29 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.024 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 98%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 2%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00055 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

In Vivo Mode of Delivery Intravenous

Transport Type Saturable

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous