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Peptide record

TPDB93304

Exendin-3 Blood-Brain Barrier standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB93304
Exendin-3
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
BBPpredict Peptipedia
standard
No
A 39-aa standard natural blood-brain barrier peptide sequence curated from BBPpredict and Peptipedia, with an available 3D structural model.
C-terminal: Chemical modification N-terminal: C-terminal modification
Sequence
HSDGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Physicochemical Analysis
C184H281N49O62S1
CY
S
4203.61
4.43
4
6
11
-3
11.59
-0.703
52.56
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5500
130.84
10
Residue Composition
number
2
A
1
R
1
N
2
D
0
C
4
E
1
Q
4
G
1
H
1
I
3
L
2
K
1
M
2
F
4
P
6
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 2 C: 0 E: 4 Q: 1 G: 4 H: 1 I: 1 L: 3 K: 2 M: 1 F: 2 P: 4 S: 6 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
39
C184H281N49O62S1
4203.61
4.43
-3
11.59
-0.703
Chemical modification
Linear
C-terminal modification
Similarity
His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser
[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.00087 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

rat
Intravenous
Saturable
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.0102 ml/g

Assay & Model

Origin/Source
Initial distribution volume

Source & Reference

NA
B3Pdb

Other

rat
Intravenous
Permeability
Direct iodination
Additional Detail Fields 1 fields
Intravenous