TPDB

3D PDB MODEL

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TPDB ID TPDB93303

Peptide_Name

Exendin-1

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

BBPpredict Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 38-aa standard natural blood-brain barrier peptide sequence curated from BBPpredict and Peptipedia, with an available 3D structural model.

Modification

C-terminal: Chemical modification N-terminal: C-terminal modification

Sequence

HSDATFTAEYSKLLAKLALQKYLESILGSSTSPRPPSS

FASTA

>TPDB93303|Blood-Brain Barrier|length=38
HSDATFTAEYSKLLAKLALQKYLESILGSSTSPRPPSS

Formula C183H293N47O59

Absent Amino Acids NCMWV

Common Amino Acids S

Mass 4095.62

PI 9.45

Basic Residues 5

Acidic Residues 3

Hydrophobic Residues 14

Net Charge +1

Boman Index 6.05

Hydrophobicity -0.326

Aliphatic Index 82.37

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 72.76

Polar Residues 14

number

4

A

1

R

0

N

1

D

0

C

2

E

1

Q

1

G

1

H

1

I

6

L

3

K

0

M

1

F

3

P

8

S

3

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 4 R: 1 N: 0 D: 1 C: 0 E: 2 Q: 1 G: 1 H: 1 I: 1 L: 6 K: 3 M: 0 F: 1 P: 3 S: 8 T: 3 W: 0 Y: 2 V: 0

Length

38

Formula

C183H293N47O59

Mass

4095.62

PI

9.45

Net Charge

+1

Boman Index

6.05

Hydrophobicity

-0.326

C_terminal_Modification

Chemical modification

Conformation

Linear

N_terminal_Modification

C-terminal modification

Peptide_Length

Similarity

Peptide_Sequence_3Letter

His-Ser-Asp-Ala-Thr-Phe-Thr-Ala-Glu-Tyr-Ser-Lys-Leu-Leu-Ala-Lys-Leu-Ala-Leu-Gln-Lys-Tyr-Leu-Glu-Ser-Ile-Leu-Gly-Ser-Ser-Thr-Ser-Pro-Arg-Pro-Pro-Ser-Ser

SMILES

CCC(C)C(C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)N2CCCC2C(=O)N3CCCC3C(=O)NC(CO)C(=O)NC(CO)C(=O)O)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CC6=CC=CC=C6)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CC7=CN=CN7)N

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0002979 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.001192 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial distribution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous