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Peptide record

TPDB93302

[Tyr10] Secretin-27 Blood-Brain Barrier standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB93302
[Tyr10] Secretin-27
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 27-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
C-terminal: Chemical modification N-terminal: C-terminal modification
Sequence
HSDGTFTSEYSRLRDSARLQRLLQGLV
Physicochemical Analysis
C133H217N43O43
NCIKMPW
L
3106.45
9.87
5
3
9
+1
5.69
-0.652
86.67
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
47.96
9
Residue Composition
number
1
A
4
R
0
N
2
D
0
C
1
E
2
Q
2
G
1
H
0
I
5
L
0
K
0
M
1
F
0
P
4
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 2 C: 0 E: 1 Q: 2 G: 2 H: 1 I: 0 L: 5 K: 0 M: 0 F: 1 P: 0 S: 4 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
27
C133H217N43O43
3106.45
9.87
+1
5.69
-0.652
Chemical modification
Linear
C-terminal modification
Similarity
His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val
[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=O
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.000899 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Gila monster
Intravenous
non saturable
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.0121 ml/g

Assay & Model

Origin/Source
Initial distribution volume

Source & Reference

NA
B3Pdb

Other

Gila monster
Intravenous
non saturable
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
2%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

Gila monster
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
98%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

Gila monster
Direct iodination
Additional Detail Fields 1 fields
Intravenous