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Peptide record

TPDB93298

Enatiomeric parent p Parent peptide Blood-Brain Barrier Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB93298
Enatiomeric parent p Parent peptide
Blood-Brain Barrier Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Blood-Brain Barrier and Tumor-homing Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidated
Sequence
THRPPMWSPVWP
Physicochemical Analysis
C71H99N19O15S1
ANDCEQGILKFY
P
1490.75
11.05
2
0
4
+1
-0.02
-0.942
24.17
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
11000
737.89
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
1
M
0
F
4
P
1
S
1
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 1 F: 0 P: 4 S: 1 T: 1 W: 2 Y: 0 V: 1
Chemical Descriptors
12
C71H99N19O15S1
1490.75
11.05
+1
-0.02
-0.942
Amidated
Linear
Similarity
ThrHisArgProProMetTrpSerProValTrpPro
Evidence Records 8 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

Rat astrocyte

Assay & Model

50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
12.5+/- 3.4 apparent permeability
Origin/Source

Source & Reference

NA
B3Pdb

Other

can transport cargo
Evidence 2 Activity

Activity

Blood-Brain Barrier

Target

Rat astrocyte

Assay & Model

50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
14.5+/- 2.0 apparent permeability
Origin/Source

Source & Reference

NA
B3Pdb

Other

can transport cargo
Evidence 3 Activity

Activity

Blood-Brain Barrier

Target

Rat astrocyte

Assay & Model

50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
14.9+/- 2.5 apparent permeability
Origin/Source

Source & Reference

NA
B3Pdb

Other

can transport cargo
Evidence 4 Activity

Activity

Blood-Brain Barrier

Target

Rat astrocyte

Assay & Model

50 micromolar
HPLC, MALDI-TOF to analyze the peptide transport and apparent permeability
17.2+/- 1.2 apparent permeability
Origin/Source

Source & Reference

NA
B3Pdb

Other

can transport cargo
Evidence 5 Activity

Activity

Blood-Brain Barrier

Target

Rat astrocyte

Assay & Model

50 micromolar
PAMPA method for cargo delivery and transportation efficiency
16.2+/- 1.3 apparent permeability
Origin/Source
Antiallergic drug

Source & Reference

NA
B3Pdb

Other

can transport cargo
carboxyfluoroscein
Evidence 6 Activity

Activity

Blood-Brain Barrier

Target

Rat astrocyte

Assay & Model

50 micromolar
PAMPA method for cargo delivery and transportation efficiency
0.19.2+/- 0.07 apparent permeability
Origin/Source

Source & Reference

NA
B3Pdb

Other

can transport cargo
iron oxide nanoparticle
Evidence 7 Activity

Activity

Blood-Brain Barrier

Target

Rat astrocyte

Assay & Model

50 micromolar
PAMPA method for cargo delivery and transportation efficiency
17.1+/- 2.6 transport efficiency
Origin/Source
Antiallergic drug

Source & Reference

NA
B3Pdb

Other

can transport cargo
carboxyfluoroscein
Evidence 8 Activity

Activity

Blood-Brain Barrier

Target

Rat astrocyte

Assay & Model

50 micromolar
PAMPA method for cargo delivery and transportation efficiency
0.22+/- 0.05 transport efficiency
Origin/Source

Source & Reference

NA
B3Pdb

Other

can transport cargo
iron oxide nanoparticle