Back to search

Peptide record

TPDB93297

Linear ADTHAV Blood-Brain Barrier standard
8 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB93297
Linear ADTHAV
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 8-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
C-terminal: Amide group is attached at C-terminal N-terminal: Acetylaed at N-terminal
Sequence
TPPVSHAV
Physicochemical Analysis
C36H58N10O11
RNDCEQGILKMFWY
PV
806.92
7.85
1
0
3
+0
2.10
0.287
85.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
2
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
8
C36H58N10O11
806.92
7.85
+0
2.10
0.287
Amide group is attached at C-terminal
Linear
Acetylaed at N-terminal
Similarity
ThrProProValSerHisAlaVal
N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
Mass Spectromtery
It is able to deliver an IRdye800CW-labeled IgG monoclonal antibody into the brain.

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intracerebral ventricular
Synthesized novel cyclic peptides are able efectively modulate the BBB to enhance the delivery of mA
Combined with monoclonal antibody
Additional Detail Fields 1 fields
Intracerebral ventricular