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Peptide record

TPDB93294

RVG9R (Chimeric rabies virus glycoprotein fragment) Blood-Brain Barrier Cell-penetrating Peptides standard
41 amino acids
Basic Information
3D PDB MODEL
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TPDB93294
RVG9R (Chimeric rabies virus glycoprotein fragment)
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 41-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
Chemical: Targeting ligand mannose (MAN)
Sequence
YTIWMPENPRPGTPCDIFTNSRGKRASNGGGGRRRRRRRRR
Physicochemical Analysis
C201H334N82O55S2
QHLV
R
4843.50
12.55
13
2
7
+11
12.58
-1.759
21.46
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
6990
144.32
10
Residue Composition
number
1
A
12
R
3
N
1
D
1
C
1
E
0
Q
6
G
0
H
2
I
0
L
1
K
1
M
1
F
4
P
2
S
3
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 12 N: 3 D: 1 C: 1 E: 1 Q: 0 G: 6 H: 0 I: 2 L: 0 K: 1 M: 1 F: 1 P: 4 S: 2 T: 3 W: 1 Y: 1 V: 0
Chemical Descriptors
41
C201H334N82O55S2
4843.50
12.55
+11
12.58
-1.759
Free
Targeting ligand mannose (MAN)
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Primary Neurons, bEnd.3 Cells, And Primary Astrocytes.

Assay & Model

Male and female C57BL/6 mice
Male and female C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
pVGF/chitosan complex
Post 4 h of incubation, the bifunctionalized liposomes (RVG9RMAN, RDPMAN and CGNMAN) were found to be internalized in excess of 80% in primary neurons, bEnd.3 cells, and primary astrocytes.
In vitro and in vivo
CCSCCSSTTSSSCCCCSCGGGSSSSCCCCTTSTTGGGGCCC
Additional Detail Fields 1 fields
CCSCCSSTTSSSCCCCSCGGGSSSSCCCCTTSTTGGGGCCC