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Peptide record

TPDB93285

FAM-NFL-GGGC Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB93285
FAM-NFL-GGGC
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with 6-Carboxyfluorescein (6-Fam)
Sequence
YSSYSAPVSSSLSVRRSYSSSSGSGGGC
Physicochemical Analysis
C113H176N34O45S1
NDEQHIKMFTW
S
2762.90
9.52
2
0
7
+2
0.15
-0.357
38.21
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
4470
161.79
17
Residue Composition
number
1
A
2
R
0
N
0
D
1
C
0
E
0
Q
4
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
13
S
0
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 13 T: 0 W: 0 Y: 3 V: 2
Chemical Descriptors
28
C113H176N34O45S1
2762.90
9.52
+2
0.15
-0.357
Free
L
Linear
Conjugated with 6-Carboxyfluorescein (6-Fam)
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U-87 Mg Human Gbm Cells And B.End3 Murine Endothelial Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM dye
Cytoplasm and Nuclei
Both via active and passive mechanisms in U-87 MG cells and energy-dependent mechanisms in b.End3 cells
In vitro
CTTCCCSCCCCCCCCCEEETTEEECSCC
Additional Detail Fields 1 fields
CTTCCCSCCCCCCCCCEEETTEEECSCC