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Peptide record

TPDB93268

TAT-PTD Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB93268
TAT-PTD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: iRGD peptide
Sequence
YGRKKRRQRRRGC
Physicochemical Analysis
C69H126N34O16S1
ANDEHILMFPSTWV
R
1720.04
12.41
8
0
1
+8
6.26
-2.915
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
86.63
3
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
2
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C69H126N34O16S1
1720.04
12.41
+8
6.26
-2.915
Free
iRGD peptide
L
Cationic
Linear
Free
NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)/N=C/C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

SUIT-2, MDA-MB-231, bEnd3 mouse endothelial, 4T1 mouse breast cancer cell

Assay & Model

Male BALB/c nude mice bearing tumor
Male BALB/c nude mice bearing tumor

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
AlexaFluor 546 (AF546) fluorescent dye
iRGD enhanced the tumor delivery of OH-N
Transcytosis
In vitro and in vivo
CCCCCTTC
Additional Detail Fields 1 fields
CCCCCTTC