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Peptide record

TPDB93261

Cysteine-TAT Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB93261
Cysteine-TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: Lipid-encapsulated AuNPs
Sequence
YGRKKRRQRRRC
Physicochemical Analysis
C67H123N33O15S1
ANDEHILMFPSTWV
R
1662.99
12.41
8
0
1
+8
6.25
-3.125
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
89.60
3
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C67H123N33O15S1
1662.99
12.41
+8
6.25
-3.125
Addition of Cysteine
Lipid-encapsulated AuNPs
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A375 Cells

Assay & Model

Human melanoma(A375 cells)-bearing Balb/c nude mice
Human melanoma(A375 cells)-bearing Balb/c nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Cas9-sgPlk-1 plasmids (Cy3-labeled CP)
Nuclei
24 h after injections, the LACP group still displayed high intensity of fluorescence in the tumor tissue, whereas other groups(CP, lipo2000/CP, and ACP groups) showed no fluorescence in the tumors.
Endosome/lysosome pathway
In vitro and in vivo
CCSCGGGCCSSCCCCCSCCCCCCCC
Additional Detail Fields 1 fields
CCSCGGGCCSSCCCCCSCCCCCCCC