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Peptide record

TPDB93260

Bio-TAT Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB93260
Bio-TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: Bio-aptamer N-terminal: Biotinylation
Sequence
YGRKKRRQRRRC
Physicochemical Analysis
C67H123N33O15S1
ANDEHILMFPSTWV
R
1662.99
12.41
8
0
1
+8
6.25
-3.125
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
89.60
3
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C67H123N33O15S1
1662.99
12.41
+8
6.25
-3.125
Addition of Cysteine
Bio-aptamer
L
Cationic
Linear
Biotinylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Crl-1596 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Protein derived
DNA nanopore
Ramos cells expected high fluorescence intensity, while HeLa cells showed no apparent fluorescent intensity for ATNP and ANP, which might be due to the specificity of aptamer to Ramos cells. HeLa cells treated with ATNP and TNP showed obvious fluorescence intensity due to the uptake of DNA nanopore in the help of TAT peptide, while for the ANP and FNP, no apparent fluorescent intensity was observed.
In vitro