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Peptide record

TPDB93256

I-TYR-L-Mca Cell-penetrating Peptides standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB93256
I-TYR-L-Mca
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 34-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
N-terminal: Conjugated with radio-ionized Tyr residue
Sequence
YGDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR
Physicochemical Analysis
C165H285N57O48S6
AQMFWV
K
4027.79
9.54
12
4
5
+7
14.84
-1.288
45.88
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1865
46.30
11
Residue Composition
number
0
A
4
R
2
N
2
D
6
C
2
E
0
Q
2
G
1
H
1
I
3
L
7
K
0
M
0
F
1
P
1
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 2 D: 2 C: 6 E: 2 Q: 0 G: 2 H: 1 I: 1 L: 3 K: 7 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
34
C165H285N57O48S6
4027.79
9.54
+7
14.84
-1.288
Free
L
Cationic
Linear
Conjugated with radio-ionized Tyr residue
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

F98 glioma cell culture

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Radiolabelled Iodine (125I)
Cytoplasm and nucleus
Uptake was dose dependent and peptides were resistant to cleavage by enzyme
In vitro
CCCCSSSTTSCCCGGGHHHHTSSSSCSGGGTCC
Additional Detail Fields 1 fields
CCCCSSSTTSCCCGGGHHHHTSSSSCSGGGTCC