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Peptide record

TPDB93255

Hph-1 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB93255
Hph-1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: Conjugation with 6-histidine tag
Sequence
YARVRRRGPRR
Physicochemical Analysis
C60H107N29O13
NDCEQHILKMFSTW
R
1442.70
12.70
6
0
3
+6
4.28
-2.209
35.45
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
103.28
1
Residue Composition
number
1
A
6
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
11
C60H107N29O13
1442.70
12.70
+6
4.28
-2.209
Free
L
Cationic
Linear
Conjugation with 6-histidine tag
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Assay & Model

Male C57BL/6J (H-2b) mice
Male C57BL/6J (H-2b) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nucleic acid (Hph1Hph1dsRBD/FAM-labeled siRNA complex)
Highly efficient at delivering siRNA in vitro
In vitro and in vivo
CCCCSSCCSCC
Additional Detail Fields 1 fields
CCCCSSCCSCC