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Peptide record

TPDB93233

GALA Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB93233
GALA
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Chemical: Nanoparticle N-terminal: Azide-Modified
Sequence
WEAALAEALAEALAEHLAEALAEALEALAA
Physicochemical Analysis
C136H215N33O45
RNDCQGIKMFPSTYV
A
3032.40
3.50
1
7
22
-7
6.95
0.773
137.67
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
181.37
0
Residue Composition
number
14
A
0
R
0
N
0
D
0
C
7
E
0
Q
0
G
1
H
0
I
7
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 14 R: 0 N: 0 D: 0 C: 0 E: 7 Q: 0 G: 0 H: 1 I: 0 L: 7 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
30
C136H215N33O45
3032.40
3.50
-7
6.95
0.773
Free
Nanoparticle
L
Linear
Azide-Modified
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dc 2.4, D1 Spleen-Derived Cell Line , RAW 264.7,Hek 293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Cy5-mRNA (Luc andEGFP) polyplexes (PPx)
Cytosol and Nucleus
PPx-GALA formulations with a high peptide density showed the highest EGFP expression with 28% transfection efficiency.
Sialic acid-terminated glycan-mediated endocytosis and phagocytosis
In vitro
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC