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Peptide record

TPDB93232

DEN-K(GALA)-TAT (Pep 9) Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB93232
DEN-K(GALA)-TAT (Pep 9)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: Poly-L-lysine dendrons (DEN)
Sequence
WEAALAEALAEALAEHLAEALAEALEALAA-NH2
Physicochemical Analysis
C136H215N33O45
RNDCQGIKMFPSTYV
A
3032.40
3.50
1
7
22
-7
6.95
0.773
137.67
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
181.37
0
Residue Composition
number
14
A
0
R
0
N
0
D
0
C
7
E
0
Q
0
G
1
H
0
I
7
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 14 R: 0 N: 0 D: 0 C: 0 E: 7 Q: 0 G: 0 H: 1 I: 0 L: 7 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
30
C136H215N33O45
3032.40
3.50
-7
6.95
0.773
Amidation
Poly-L-lysine dendrons (DEN)
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
YOYO-1 labelled pEGFP plasmid
Cytoplasm and nucleus
Improved cellular uptake of pep 9 was ∼70 % at N/P 5
In vitro
CCSCCCHHHHHHHHHHHHCCC
Additional Detail Fields 1 fields
CCSCCCHHHHHHHHHHHHCCC