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Peptide record

TPDB93231

LMWP Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB93231
LMWP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: PEG conjugated to siRNA via disulphide linkage [LMWP-PEG–S–S–siRNA] N-terminal: PEGylation
Sequence
VSRRRRGGRRRRRR
Physicochemical Analysis
C72H142N44O16
ANDCEQHILKMFPTWY
R
1880.20
13.35
10
0
1
+10
8.32
-3.029
20.71
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C72H142N44O16
1880.20
13.35
+10
8.32
-3.029
Free
PEG conjugated to siRNA via disulphide linkage [LMWP-PEG–S–S–siRNA]
L
Linear
PEGylation
N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hct 116 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
TAMRA- labelled anti-EGFP siRNA
Cytosol
LMWP–PEG–S–S–siRNA conjugate was 35.6-fold higher than native siRNA without LMWP modification.
In vitro
CCCCCSCCCCCCCC
Additional Detail Fields 1 fields
CCCCCSCCCCCCCC