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Peptide record

TPDB93220

DPV1047 Blood-Brain Barrier Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB93220
DPV1047
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 19-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict, CellPPD, CPPsite3.0, and other sources, with an available 3D structural model.
N-terminal: Cys addition
Sequence
VKRGLKLRHVRPRVTRMDV
Physicochemical Analysis
C100H182N38O23S1
ANCEQIFSWY
R
2316.85
12.58
8
1
7
+6
7.75
-0.705
102.11
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
5
R
0
N
1
D
0
C
0
E
0
Q
1
G
1
H
0
I
2
L
2
K
1
M
0
F
1
P
0
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 2 K: 2 M: 1 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
19
C100H182N38O23S1
2316.85
12.58
+6
7.75
-0.705
Free
L
Linear
Cys addition
N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, HCT116, HL-60, K562, Molt4, NIH-3T3 and primary hepatocyte cultures

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Protein (PO and IgG)
Nucleus
Lower than other DPVs and tat (48-60)
Energy-dependent caveolar endocytic independent mechanism
In vitro
CCSSCCCCSSCCCCSCCC
Additional Detail Fields 1 fields
CCSSCCCCSSCCCCSCCC