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Peptide record

TPDB93218

PEPth Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB93218
PEPth
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Cyto-Tag (GFP11-SBP2)
Sequence
VKKKKIKAEIKI
Physicochemical Analysis
C67H128N18O15
RNDCQGHLMFPSTWY
K
1425.87
10.82
6
1
5
+5
6.93
-0.617
130.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
3
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 3 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C67H128N18O15
1425.87
10.82
+5
6.93
-0.617
Free
Cyto-Tag (GFP11-SBP2)
L
Cationic
Linear
Free
N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ls174T, Mkn45, Colo320Hsr And Hek293Fs Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Parental anti-CEACAM5 antibody
Cytosol
Relatively more PEPth-AH entered the cells than PEPth-BH molecules.
In vitro
CCCCCCSCCCCC
Additional Detail Fields 1 fields
CCCCCCSCCCCC