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Peptide record

TPDB93214

HTLV -II Rex(4-16) Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB93214
HTLV -II Rex(4-16)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Conjugation with fluorescein by C-terminal Gly Cys amide
Sequence
TRRQRTRRARRNRGC
Physicochemical Analysis
C73H139N41O20S1
DEHILKMFPSWYV
R
1943.23
12.88
8
0
1
+8
7.36
-2.700
6.67
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
1
A
8
R
1
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 8 N: 1 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C73H139N41O20S1
1943.23
12.88
+8
7.36
-2.700
Conjugation with fluorescein by C-terminal Gly Cys amide
L
Cationic
Linear
Free
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

RAW 264.7

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Cytoplasm and nucleus
Comparable with that of the Tat-(48–60) peptide
Non-endocytic mechanism
In vitro
CCCCSSSSCCTTTCC
Additional Detail Fields 1 fields
CCCCSSSSCCTTTCC