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Peptide record

TPDB93206

Angiopep-2 Blood-Brain Barrier Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB93206
Angiopep-2
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 19-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Conjugated with Tratuzumab
Sequence
TFFYGGSRGKRNNFKTEEY
Physicochemical Analysis
C104H149N29O31
ADCQHILMPWV
GF
2301.50
9.97
4
2
5
+2
3.65
-1.495
0.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
2980
129.48
7
Residue Composition
number
0
A
2
R
2
N
0
D
0
C
2
E
0
Q
3
G
0
H
0
I
0
L
2
K
0
M
3
F
0
P
1
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 3 P: 0 S: 1 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
19
C104H149N29O31
2301.50
9.97
+2
3.65
-1.495
Conjugated with Tratuzumab
Linear
Similarity
ThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyr
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
10mg/Kg
Fluoroscent screening by FITC labbled peptide maass in brain tissue
Significant fluoroscdnt observed in brain tissue
Breast cancer metastasis

Source & Reference

NA
B3Pdb

Other

Intravenous
Evidence 2 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
6 ml/kg
In situ brain perfusion assay
10 time increase of Mab as compared to control in brain tissue
Breast cancer metastasis

Source & Reference

NA
B3Pdb

Other

Intravenous
Additional Detail Fields 1 fields
Intravenous