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Peptide record

TPDB93205

Angiopep2 Blood-Brain Barrier Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB93205
Angiopep2
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 19-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Chemical: FITC-labeled polymersomes (Ps)
Sequence
TFFYGGCRGKRNNFKTEEY
Physicochemical Analysis
C104H149N29O30S1
ADQHILMPSWV
GF
2317.56
9.53
4
2
5
+2
3.28
-1.321
0.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
2980
128.58
7
Residue Composition
number
0
A
2
R
2
N
0
D
1
C
2
E
0
Q
3
G
0
H
0
I
0
L
2
K
0
M
3
F
0
P
0
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 0 C: 1 E: 2 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 3 P: 0 S: 0 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
19
C104H149N29O30S1
2317.56
9.53
+2
3.28
-1.321
Free
FITC-labeled polymersomes (Ps)
L
Linear
Free
N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87Mg Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Doxorubicin (DOX)
The angiopep2-modified Ps were uptaken more efficiently than the unmodified Ps, showing 5 times more internalization by the U86MG cells.
Receptor mediated endocytosis
In vitro
CCSCC
Additional Detail Fields 1 fields
CCSCC