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Peptide record

TPDB93203

Truncated AA3H 3 Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB93203
Truncated AA3H 3
Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0 TumorHoPe2.0
standard
No
A 4-aa standard natural multi-activity (Blood-Brain Barrier, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from Peptipedia, CPPsite3.0, and TumorHoPe2.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
SIWV
Physicochemical Analysis
C25H37N5O6
ARNDCEQGHLKMFPTY
ISWV
503.60
6.02
0
0
3
-0
-1.96
1.750
170.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
1092.14
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
4
C25H37N5O6
503.60
6.02
-0
-1.96
1.750
Free
L
Hydrophobic
Linear
Conjugated with FITC
N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, U87Mg, A549 And Huh7 Cells

Assay & Model

5- or 6-week-old female BALB/c nu/nu mice or 7-week-old ICR mice
5- or 6-week-old female BALB/c nu/nu mice or 7-week-old ICR mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
FITC dye and Porous silicon nanoparticles(pSiNPs) and the drug SN-38
Cytoplasm
Showed high penetration efficiency and order of uptake is SIWV> ASIW> WVGH > IWVG
Caveolae-mediated and lipid raft-mediated endocytosis
In vitro and in vivo
CCCC
Additional Detail Fields 1 fields
CCCC