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Peptide record

TPDB93202

PepNeg Blood-Brain Barrier Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB93202
PepNeg
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 7-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: GFP Via Spacer Of Glycine And Serine (SGGGGSGGGGSS)
Sequence
SGTQEEY
Physicochemical Analysis
C33H48N8O16
ARNDCHILKMFPWV
E
812.79
3.13
0
2
1
-2
3.96
-1.957
0.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
183.32
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
2
E
1
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
7
C33H48N8O16
812.79
3.13
-2
3.96
-1.957
Free
L
Anionic
Linear
GFP Via Spacer Of Glycine And Serine (SGGGGSGGGGSS)
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3 Brain Endothelial Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Anionic
Synthetic
GFP protein
The translocation of GFP_PepNeg was 1.3-times higher (42.50 ± 3.28%) than for GFP_PepH3
Macropinocytosis, and clathrin- and caveolin-independent pathways
In vitro
CCSCSCCSCSTTHHHHSCC
Additional Detail Fields 1 fields
CCSCSCCSCSTTHHHHSCC