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Peptide record

TPDB93200

SERSQ Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB93200
SERSQ
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: DTBTA-Eu3+ -labelled
Sequence
SERSQYIPSTRT
Physicochemical Analysis
C59H97N19O22
ANDCGHLKMFWV
S
1424.53
9.87
2
1
2
+1
4.09
-1.517
32.50
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
104.60
7
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
3
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 3 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C59H97N19O22
1424.53
9.87
+1
4.09
-1.517
Free
DTBTA-Eu3+ -labelled
L
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

C57BL/6 mice (female, 8–10 weeks of age) were infected subcutaneously with S. aureus Cowan I
C57BL/6 mice (female, 8–10 weeks of age) were infected subcutaneously with S. aureus Cowan I

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
LST fused at C terminal
LST_SERSQ and LST_MTPTA did not show the same tissue-specific accumulation
In vivo
CEEEETTEEEEC
Additional Detail Fields 1 fields
CEEEETTEEEEC