Back to search

Peptide record

TPDB93199

SDSSD Cell-penetrating Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB93199
SDSSD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 5-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: DTBTA-Eu3+ -labelled
Sequence
SDSSD
Physicochemical Analysis
C17H27N5O13
ARNCEQGHILKMFPTWYV
S
509.43
2.92
0
2
0
-2
2.85
-1.880
0.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
0
R
0
N
2
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 2 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C17H27N5O13
509.43
2.92
-2
2.85
-1.880
Free
DTBTA-Eu3+ -labelled
L
Linear
Free
N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

C57BL/6 mice (female, 8–10 weeks of age) were infected subcutaneously with S. aureus Cowan I
C57BL/6 mice (female, 8–10 weeks of age) were infected subcutaneously with S. aureus Cowan I

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
LST fused at C terminal
Significantly higher levels of LST_HGDWT (P = 0.033) and LST_SDSSD (P = 0.009) as compared to the parental LST were observed in bone
In vivo
CCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCC