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Peptide record

TPDB93191

Pip6a Cell-penetrating Peptides modified_plain modified
22 amino acids
Basic Information
3D PDB MODEL
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TPDB93191
Pip6a
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 22-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Acylation
Sequence
RXRRBRRXRYQFLIRXRBRXRB
Physicochemical Analysis
C95H170N46O18
ANDCEGHKMPSTWV
R
2244.69
13.00
10
0
4
+10
5.74
-1.759
35.45
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
66.38
2
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
22
C95H170N46O18
2244.69
13.00
+10
5.74
-1.759
Free
Modified
Linear
Acylation
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Huh7, Hek293T, HeLa, Caco-2, N2A And Hek-Bluetm Il-6 Reporter Cell Line , C2C12

Assay & Model

Female C57BL/6 mice (20 ± 5 g)
Female C57BL/6 mice (20 ± 5 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear Modified
Synthetic
PMO-modified SSOs
PMO SSO to Pip6a enhanced the delivery in vitro, with up to 90% exon skipping observed at a 10 μM concentration.
In vitro and in vivo
CCCCC
Additional Detail Fields 1 fields
CCCCC