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Peptide record

TPDB93186

9b2 Cell-penetrating Peptides modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB93186
9b2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 18-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Acetylation
Sequence
Ac-RXRRBRRFQILYRBRXRB
Physicochemical Analysis
C83H146N38O16
ANDCEGHKMPSTWV
R
1932.32
12.88
8
0
4
+8
4.12
-1.650
43.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
77.11
2
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
18
C83H146N38O16
1932.32
12.88
+8
4.12
-1.650
Free
Modified
Linear
Acetylation
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Immortalized Myod-Inducible (Doxycycline) Dm1

Assay & Model

Homozygous transgenic HSALR (line 20 b) mice
Homozygous transgenic HSALR (line 20 b) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear Modified
PMO against miR23b and PMO against miR-218
Nucleus
CPP-PMOs(antimiR against miR-23b or against miR-218.) linked to 9b2 induced a 4-fold increase in MBNL1 at 200 nM concentration.
Gymnotic delivery
In vitro and in vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC