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Peptide record

TPDB93185

[RW]6 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB93185
[RW]6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
RWRWRWRWRWRW
Physicochemical Analysis
C102H134N36O13
ANDCEQGHILKMFPSTYV
RW
2072.42
13.10
6
0
6
+6
-6.24
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
33000
1592.34
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
12
C102H134N36O13
2072.42
13.10
+6
-6.24
-2.700
Free
L
Amphiphilic
Linear
Conjugated with FITC
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
Gemcitabine (Gem) and FITC dye
Cytoplasm, Nucleus And Nucleoli
Concentration-dependent internalization
In vitro
CCSCCCCSSTTCSCCCC
Additional Detail Fields 1 fields
CCSCCCCSSTTCSCCCC