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Peptide record

TPDB93184

[RW]6 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB93184
[RW]6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: E9 peptide
Sequence
RWRWRWRWRWRW
Physicochemical Analysis
C102H134N36O13
ANDCEQGHILKMFPSTYV
RW
2072.42
13.10
6
0
6
+6
-6.24
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
33000
1592.34
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
12
C102H134N36O13
2072.42
13.10
+6
-6.24
-2.700
Free
E9 peptide
L
Cationic
Cyclic
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
FITC dye
Nucleus
Uptake of R5W3R4 peptide is better than R9 and [RW]6
Direct translocation and endocytosis
In vitro
CCSCCC
Additional Detail Fields 1 fields
CCSCCC