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Peptide record

TPDB93181

R5W3R4 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB93181
R5W3R4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
RRRRRWWWRRRR
Physicochemical Analysis
C87H140N42O13
ANDCEQGHILKMFPSTYV
R
1982.34
13.30
9
0
3
+9
1.74
-3.600
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
832.35
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
12
C87H140N42O13
1982.34
13.30
+9
1.74
-3.600
Free
L
Amphiphilic
Linear
Conjugated with FITC
N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
Gemcitabine (Gem) and FITC dye
Cytoplasm, Nucleus And Nucleoli
Maximum intracellular fluorescence relative to other peptides
In vitro
CTTCCCGGGGGGTSCCC
Additional Detail Fields 1 fields
CTTCCCGGGGGGTSCCC