Back to search

Peptide record

TPDB93175

CPP-FITC Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB93175
CPP-FITC
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
C-terminal: Amidation Chemical: FITC-labelled at C terminus via Lys and PEGylated
Sequence
RRRRRRRRRK-NH2
Physicochemical Analysis
C60H122N38O11
ANDCEQGHILMFPSTWYV
R
1551.88
13.30
10
0
0
+10
8.28
-4.440
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C60H122N38O11
1551.88
13.30
+10
8.28
-4.440
Amidation
FITC-labelled at C terminus via Lys and PEGylated
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 Human Breast Cancer Cell Line

Assay & Model

Male Sprague Dawley rats (200±20 g) and BALB/c nude mice (20±2 g)
Male Sprague Dawley rats (200±20 g) and BALB/c nude mice (20±2 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Doxorubicin (DOX)
Cytosol
distribution of DOX-4%CPPL in the cytosol increased 1.6 times compared to DOX-PSL as well as DOX-4%CPL at pH 6.0.
In vitro and in vivo
CCCCCCGGGC
Additional Detail Fields 1 fields
CCCCCCGGGC