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Peptide record

TPDB93172

oligoarginine(R9) Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB93172
oligoarginine(R9)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: Nanogel (NG)
Sequence
RRRRRRRRRC
Physicochemical Analysis
C57H115N37O11S1
ANDEQGHILKMFPSTWYV
R
1526.84
12.94
9
0
0
+9
7.05
-3.800
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
9
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C57H115N37O11S1
1526.84
12.94
+9
7.05
-3.800
Addition of Cysteine
Nanogel (NG)
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bc 5637 Cells

Assay & Model

Male C57Bl/6 mice weighing 18 − 20 g and Sprague-Dawley (SD) rats weighing 170 − 200 g
Male C57Bl/6 mice weighing 18 − 20 g and Sprague-Dawley (SD) rats weighing 170 − 200 g

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
10-hydroxycamptothecin (HCPT)
The cells treated with R9NG/HCPT exhibited more robust HCPT fluorescence than that of free HCPT or NG/HCPT for the co-incubation period of 6 h. The increased HCPT concentration in the cells of the R9NG/HCPT group was about 1.9 times with free HCPT and about 1.5 times with the NG/HCPT group at 6 h.
In vitro and in vivo
CCSCGGGCTTTCCSCGGGSCCC
Additional Detail Fields 1 fields
CCSCGGGCTTTCCSCGGGSCCC