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Peptide record

TPDB93171

R8 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB93171
R8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
N-terminal: Conjugation with 5-carboxyfluorescein via a lysine residue
Sequence
RRRRRRRRK
Physicochemical Analysis
C54H110N34O10
ANDCEQGHILMFPSTWYV
R
1395.69
13.25
9
0
0
+9
7.47
-4.433
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C54H110N34O10
1395.69
13.25
+9
7.47
-4.433
Free
L
Cationic
Linear
Conjugation with 5-carboxyfluorescein via a lysine residue
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Wong-Kilbourne-derived human conjunctival epithelial cells (NHC)

Assay & Model

Male SpragueDawley rats and male albino rabbits
Male SpragueDawley rats and male albino rabbits

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore [5-carboxyfluorescein (FAM)]
Lower uptake efficiency
In vitro and in vivo
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC