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Peptide record

TPDB93170

Stearyl R8H3 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB93170
Stearyl R8H3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
N-terminal: Stearylation
Sequence
RRRRRRRRHHH
Physicochemical Analysis
C66H119N41O12
ANDCEQGILKMFPSTWYV
R
1678.94
13.25
11
0
0
+8
9.36
-4.145
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
3
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C66H119N41O12
1678.94
13.25
+8
9.36
-4.145
Free
L
Cationic
Linear
Stearylation
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

B16F10 tumour-bearing mice
B16F10 tumour-bearing mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Cou6 -labelled Docetaxel-loaded transfersomes (DTX-Ts)
In-vivo treatment with Cou6-CTs/Gel resulted in a high Cou6 fluorescent signal distributing in both the skin layer and tumour site compared to weak signals at both the skin layer and tumour site after the Cou6-Ts/Gel treatment, suggesting CTs/Gel enhanced skin and tumour penetration capability.
In vivo
CCCCTTSCCCCHHHHSSCCCCC
Additional Detail Fields 1 fields
CCCCTTSCCCCHHHHSSCCCCC