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Peptide record

TPDB93169

R8-FL Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB93169
R8-FL
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-RRRRRRRRGC-NH2
Physicochemical Analysis
C53H106N34O11S1
ANDEQHILKMFPSTWYV
R
1427.71
12.88
8
0
0
+8
6.25
-3.390
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
8
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C53H106N34O11S1
1427.71
12.88
+8
6.25
-3.390
Amidation
L
Cationic
Linear
Acetylation
N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
5–(iodoacetamido)fluorescein and FTase inhibitor, FTI277 at cysteine at C terminus
Cytosol
The cellular uptake of the R8-FL peptide was 2.6 times lesser than for DPA-R8-FL without metal ions.
Direct translocation
In vitro and ex vivo
CTTSCGGGGTCC
Additional Detail Fields 1 fields
CTTSCGGGGTCC