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Peptide record

TPDB93166

R8 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB93166
R8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and Peptipedia, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: N-(2-hydroxypropyl) methacrylamide (HPMA) ploymer
Sequence
RRRRRRRRC
Physicochemical Analysis
C51H103N33O10S1
ANDEQGHILKMFPSTWYV
R
1370.65
12.88
8
0
0
+8
6.24
-3.722
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
8
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C51H103N33O10S1
1370.65
12.88
+8
6.24
-3.722
Addition of Cysteine
N-(2-hydroxypropyl) methacrylamide (HPMA) ploymer
L
Cationic
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

4T1 And MDA-MB-231 Cells

Assay & Model

Female BALB/c mice (4-6 weeks)
Female BALB/c mice (4-6 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Doxorubicin (DOX)
Cytoplasm and nucleus
P-D-R8 showed enhanced cellular uptake with 1.44-fold higher than PD at 4 h.
More than one endocytosis pathways including macropinocytosis
In vitro and in vivo
CCSSSSSSCCCCTHHHHHSTTCCCC
Additional Detail Fields 1 fields
CCSSSSSSCCCCTHHHHHSTTCCCC