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Peptide record

TPDB93164

peptide 2 peptide 6 Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB93164
peptide 2 peptide 6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 7-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-RRRRRRK-NH2
Physicochemical Analysis
C42H86N26O8
ANDCEQGHILMFPSTWYV
R
1083.31
13.10
7
0
0
+7
5.85
-4.414
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C42H86N26O8
1083.31
13.10
+7
5.85
-4.414
Amidation
L
Cationic
Linear
Acetylation
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hl-60, MCF-7, MDA-MB-231, CHO-K1 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
5(6)–carboxy-fluorescein (Cf) on C-terminal lysin
Cytosol
Peptide 2 derivative showed higher internalisation than the peptide 1.
In vitro
CCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hl-60, MCF-7, MDA-MB-231, CHO-K1 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Synthetic
5(6)–carboxytetramethylrhodamine (Rh) on C-terminal lysin
Cytosol
In HeLa cells, the cellular uptake profile of peptide 6 was similar to Cf labelled peptide on HL-60 cells.
In vitro
Additional Detail Fields 1 fields
CCCCC