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Peptide record

TPDB93162

SAR6EW Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB93162
SAR6EW
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 8-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Stearylation
Sequence
RRRRRREW
Physicochemical Analysis
C52H91N27O11
ANDCQGHILKMFPSTYV
R
1270.47
12.70
6
1
1
+5
5.03
-3.925
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
432.91
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
8
C52H91N27O11
1270.47
12.70
+5
5.03
-3.925
Free
L
Amphiphilic
Linear
Stearylation
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cell Monolayer

Assay & Model

Male Wistar rats
Male Wistar rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
Insulin
Transport was in this order: SAR6EW-insulin > R6EW-insulin > R8-insulin > insulin.
Energy dependent pathway route and direct penetration
In vitro and in vivo
CCGGGCSTTTC
Additional Detail Fields 1 fields
CCGGGCSTTTC