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Peptide record

TPDB93160

FHV coat (35-49) Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB93160
FHV coat (35-49)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Conjugation with Alexa 488 at glycyl cysteine sequence
Sequence
RRRRNRTRRNRRRVRGC
Physicochemical Analysis
C88H170N52O21S1
ADEQHILKMFPSWY
R
2324.71
13.05
11
0
1
+11
9.73
-2.994
17.06
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
4
Residue Composition
number
0
A
11
R
2
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 11 N: 2 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C88H170N52O21S1
2324.71
13.05
+11
9.73
-2.994
Conjugation with Alexa 488 at glycyl cysteine sequence
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1, HeLa and Jurkat

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (Alexa-488)
Punctate distribution (vesicles) with diffuse flurescence in cytosole and
2.7–6.4 times more than the Rev peptide
Endocytic pathway (Macropinocytosis)
In vitro
CCSSCTTTCCSSCCCCC
Additional Detail Fields 1 fields
CCSSCTTTCCSSCCCCC