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Peptide record

TPDB93158

nrdfTAT Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB93158
nrdfTAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: bis(maleimido)ethane added
Sequence
RRRQRRKKRGYCKCKYGRKKRRQRRR
Physicochemical Analysis
C146H268N70O31S2
ANDEHILMFPSTWV
R
3564.30
12.56
18
0
2
+18
14.48
-3.185
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
3105
87.11
6
Residue Composition
number
0
A
12
R
0
N
0
D
2
C
0
E
2
Q
2
G
0
H
0
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 2 E: 0 Q: 2 G: 2 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
26
C146H268N70O31S2
3564.30
12.56
+18
14.48
-3.185
Free
L
Cationic
Linear
bis(maleimido)ethane added
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Neuro-2a and HDF cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (TMR)
Cytosol and Nucleus
Macropinocytosis
In vitro
CCCCSTTSSCCCSCCCCTTGGGTCCC
Additional Detail Fields 1 fields
CCCCSTTSSCCCSCCCCTTGGGTCCC