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Peptide record

TPDB93139

Penetratin Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB93139
Penetratin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and Peptipedia, with an available 3D structural model.
Chemical: Mannose (MAN) modified liposomes
Sequence
RQIKIWFQNRRMKWKKGG
Physicochemical Analysis
C108H174N36O22S1
ADCEHLPSTYV
K
2360.86
12.72
7
0
6
+7
2.31
-1.583
43.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
465.93
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
2
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
18
C108H174N36O22S1
2360.86
12.72
+7
2.31
-1.583
Free
Mannose (MAN) modified liposomes
L
Cationic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Primary Neurons, Primary Astrocytes, And bEnd.3 Cells (Obtained From 1-Day Old Sprague–Dawley Rat Pup Brains )

Assay & Model

C57BL/6 mice
C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
ApoE2 encoding plasmid DNA (pApoE2)
Nucleus
PenMAN-liposomes resulted in slightly higher transfection than RVGMAN-liposomes
Energy dependent pathway
In vitro and in vivo
CCSCCSCCCSSSSCCCSTTTCSTTTSCCC
Additional Detail Fields 1 fields
CCSCCSCCCSSSSCCCSTTTCSTTTSCCC